Last issue we had a relatively few characters vital to the storyline. In contrast, after looking at the cover of Marvel Team-Up #83, we see things have gotten a bit more crowded! The amnesiac Black Widow from last issue also appears in this issue, but it is Spider-Man (of course!) and Nick Fury who are the headliners. Wait a minute! You may ask why is Spider-Man and the Black Widow even on the cover since they were shot at the end of last issue by Nick Fury? Well, we have to read on to see!

"Slaughter On 10th Avenue!" begins with Spider-Man laying in the snow on the rooftop of a building where he and the Black Widow battled S.H.I.E.L.D. Strike Force Units last issue, seemingly dead. But this is a comic book, and of course Peter finally realizes that he was shot by an anesthetic bullet, from the same gun that Fury used to shoot the Widow just seconds before Spider-Man. Spider-Man is now set on finding out just what the heck is going on, and swings away. At the same time, in S.H.I.E.L.D.'s New York Headquarters in a tall skyscraper, Nick Fury and Jasper Sitwell have about the Black Widow. The Widow is now unconscious, weakened by the tranquilizer that Fury shot into her. They need her awake, as before the Widow became amnesiac and disappeared, she called Fury and warned him about some imminent terrible disaster. Fury is also angry since he never ordered the Strike Force Units to shoot to kill.

Peter Parker now knows that he needs to find the headquarters of S.H.I.E.L.D., and makes a visit to the Daily Bugles chief librarian: Maggie McCulloch for help. Peter finally finds what he is looking for and makes his way into the building. At the same time, a doctor overlooking the Widow is somehow hypnotized and ordered to kill her. Just as the doctor is about to stab her, the Widow lands a powerful blow to the doc and knocks him out. She is obviously now awake and suits up as the Black Widow once again. After knocking out a security guard, the Widow meets Spider-Man again and they escape, just as the alarms go off throughout the building.

Eighty miles away from Manhattan aboard the S.H.I.E.L.D. Heli-Carrier, Clay Quartermain is receiving a report that the Widow has escaped. A mysterious female Commander receives the report from a seemingly hypnotized Quartermain, and then gives instructions to the villains Boomerang and the defiant Silver Samurai to go and kill Spider-Man and the Black Widow. We all Boomerang has been a second-rate villain of Spider-Man and many other foes over the years, and the Silver Samurai has unfinished business with Spider-Man after their last meeting in Marvel Team-Up #74. At the same time in the Chinatown section of New York, Nick Fury realizes that someone is trying to take over S.H.I.E.L.D., and that he cannot truly trust anyone at the moment. Unknown to Fury at that moment, is that Boomerang is watching his every move, having his car bugged by a hypnotized technician.

At Peter Parker's apartment lies the Black Widow, awaking again. Peter states that Spider-Man brought her there and offers her food. Her memory seems to be coming back to her now, as she screams with many a memory flooding her thoughts. Just as Peter calms her down and consoles her, Nick Fury kicks the door down and "arrests" them both for treason. As they walk out to get into Nick's car, it blows up. Miraculously, no one is injured, but the ambush begins, as Boomerang begins his assault on the trio of heroes. Boomerang throws all sorts of "toys" at the three, but is eventually tackled by Spider-Man. Boomerang's boot-jets blast Spidey far off of him and into the arms of the Black Widow, saving him. Boomerang now has his eyes set on Fury, as he throws a razor-sharp boomerang through Fury's gun. Spider-Man again saves the day by and knocks him out silly. The three think they are safe, but nothing can be further from the truth, as out of nowhere: The Silver Samurai teleports in front of them swinging away at Spider-Man with his samurai sword. Remember now, the Silver Samurai stole a teleport ring from John Belushi in Marvel Team-Up #74 (I know, it sounds crazy!). If that isn't bad enough, Boomerang comes to, and the two villains quickly rush the three heroes. They suddenly stop, but why? It seems that they have to heed the orders from their mistress, as there is too much at stake to risk defeat at that time. The Samurai then uses his teleport ring and teleports him and Boomerang away to who-knows-where!

The three heroes now are still bewildered by what has been going on these last two issues, but things will become much clearer next issue when Shang-Chi, Master Of Kung-Fu joins in on the action, making this a very crowded team-up title!